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رکورد قبلیرکورد بعدی
نوع مدرک : TF
زبان مدرک : فارسی
شماره رکورد : 67050
شماره مدرک : ‭پ۵۳۵۲۵‬
شماره راهنما : ‭ت۲۶۶۶‬
سر شناسه : فخاریان تربتی، طاهره
عنوان اصلي : بررسی فراوانی پلی مورفیسم تک نوکلئوتیدی‭rs8099917‬ و‭rs12979860‬ نزدیک ژن‭IL28B‬ در بیماران با هپاتیت مزمن و سیروز به علت هپاتیت‭C‬
نام عام مواد : [پایان‌نامه]
نام نخستين پديدآور : /طاهره فخاریان تربتی
نام ساير پديدآوران : ؛استاد راهنما: علی بهاری
نام ساير پديدآوران : ؛استاد مشاور: محمد خواجه دلوئی
عنوان ديگر : عنوان به انگلیسی‭Evaluation of single nucleutide polymorphisms (SNP) near the interleukin 28B gene locus (rs8099917 & rs12979860) in patients with choronic hepatitis and cirrhosis due to HCV infection :‬
وضعيت نشر : دانشگاه علوم پزشکی مشهد، ‭۱۳۹۲‬، دانشکده پزشکی
صفحه شمار : ‮‭[۱۱۹]‬ ص.‬: نمودار
يادداشت : چکیده فارسی، چکیده انگلیسی
يادداشت : چاپی
خلاصه يا چکيده : ‭PCR) method and their correlation with other variables such as Alt, histology and synthetic function of liver, viral load, were mentioned. Results: A totol of 119 males and 29 females were enrolled. Their mean age was 42.4-ARMS-Primer Amplification Refractory Mutation SystemPolymerase Chain Reaction (T- rs8099917 were genotyped using a Tetra&Background: Single Nucleutide Polymorphisms of IL28B have an important role in treatment response of HCV infection.Because of, long duration, expense and major side effect of treatment It seems that a comprehensive study which investigate frequency of this polymorphisms and correlation of them with laboratory findings is necessary. Method: This study was done on patients of GI clinic of Mashhad`s Emam Reza university hospital, that had chronic hepatitis or cirrhosis due to HCV infection. IL28B rs12979860‬▒‭G alleles was 58.1 , 38.5 , 3.4 , 77.36 and 22.63 . Association of two unfavourable genotypes were seen in only 2.7 . About correlation of variables only high viral load showed a meaningful correlation to unfavourable genotype of TT rs12979860 and there was`nt any correlation of Alt,synthetic function and histology of liver to IL28B genotypes. Conclusion: It seems that impact of low frequency of unfavourable genotype of rs12979869 (TT) and high frequency of favourable genotype of rs8099917 (TT) as well as low frequency of hemozygot of two unfavourable genotypes is more prominent on treatment responses than high frequency of favourable genotype of rs12979860 (CC) in Iranian HCV patients. Confirming these findings need studies with larger sample size and complementary investigations, preferably in other parts of Iran. Keywords: Single Nucleotide Polymorphism, Interleukin 28B, Cronic hepatitis C, Cirrhosis & GG genotypes and T& T alleles was 72.3 , 14.2 , 13.5 , 49.66 and 50.34 . The frequency of Il28B rs8099917 TT, TG & TT genotypes and C&12.4 years.The frequency of Il28B rs12979860 TT, CC‬
 
 
 
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