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نوع مدرک : TF
زبان مدرک : فارسی
شماره رکورد : 67005
شماره مدرک : ‭پ۵۳۴۹۸‬
شماره راهنما : ‭ت۲۶۴۷‬
سر شناسه : نوبخت، زهره
عنوان اصلي : بررسی ارتباط آدیپوسایتوکاین های لپتین و ویسفاتین با تخریب رادیوگرافیک مفصل در بیماران آرتریت روماتوئید
نام عام مواد : [پایان‌نامه]
نام نخستين پديدآور : /زهره نوبخت
نام ساير پديدآوران : ؛استاد راهنما: زهرا میرفیضی ، ژاله شریعتی
نام ساير پديدآوران : ؛استاد مشاور: محمد رضا هاتف ، محمد حسن جوکار ، هوشنگ رفعت پناه ، حبیب الله اسماعیلی
عنوان ديگر : عنوان به انگلیسی‭Evaluation of relationship between serum level of Adipocytokin leptin and Visfatin with Radiographic Joint Damage score in Rheumatoid Arthritis :‬
وضعيت نشر : دانشگاه علوم پزشکی مشهد، ‭۱۳۹۱‬، دانشکده پزشکی
صفحه شمار : ‮‭[۹۲]‬ ص.‬: مصور
يادداشت : چکیده فارسی ، چکیده انگلیسی
يادداشت : چاپی
خلاصه يا چکيده : ‭reactive protein levels (p=0.008) but no after adjustment for disease duration (p=0.247). The mean leptin serum levels had no different between two groups (p=0.903). There was a positive correlation between leptin levels and BMI (r=0.494, p<0.001). However, after adjustment for BMI, leptin levels had no different among two groups (p=0.508). Conclusion: Taking together, this study showed that visfatin levels were significantly higher in patients with radiographic joint damage dependently to disease duration. Therefore, it seems that this adipocytokine can be a good agent for therapeutic targets in the future. Keywords: Rheumatoid arthritis, Adipocytokine, Leptin, Visfatin, Larsen score -sectional associations with radiographic damage were explored, adjusting for pertinent confounders. Results: Concentrations of visfatin were significantly higher in patients with radiographic joint damages compared with patients without it (p=0.013). This difference remained significant after adjustment for C-nine with erosion and 25 without erosion) were enrolled. Radiographic joint damages were defined according to Larsen score. Serum levels of adipocytokines were measured and cross-5 year diagnosis of RA (twenty-four patients with 1-Introduction: Rheumatoid arthritis (RA) is usually a chronic, systemic inflammatory disorder primarily targeting the synovium and articular cartilage that lead to joint damage. Recent reports have suggested the role of adipocytokines in mediating joint damage; however it is still a matter of debate. The purpose of this study was to examine the association between serum values of adipocytokines (leptin, visfatin) and radiographic joint damage in patients with RA. Material and Methods: Fifty‬
 
 
 
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