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نوع مدرک : TF
زبان مدرک : فارسی
شماره رکورد : 66976
شماره مدرک : ‭پ۵۳۴۸۳‬
شماره راهنما : ‭ت۲۶۹۳‬
سر شناسه : طالبی، سعیده
عنوان اصلي : بررسی اثر ملاتونین بر تشنج مقاوم به درمان در کودکان
نام عام مواد : [پایان‌نامه]
نام نخستين پديدآور : /سعیده طالبی
نام ساير پديدآوران : ؛استاد راهنما: جواد آخوندیان
نام ساير پديدآوران : ؛استاد مشاور: حمید رضا کیانی فر، فرح اشرف زاده، منور افضل آقایی
عنوان ديگر : عنوان به انگلیسی‭The effect of melatonin on pediatric drug-resistant epilepsy :‬
وضعيت نشر : دانشگاه علوم پزشکی مشهد، ‭۱۳۹۱‬، دانشکده پزشکی
صفحه شمار : ‮‭[۸۹]‬ ص.‬: جدول، نمودار
يادداشت : چکیده فارسی، چکیده انگلیسی
يادداشت : چاپی
خلاصه يا چکيده : ‭resistant epilepsy, who had referred to epileptic clinic of Quaem hospital, Patients were randomly assigned to receive treatment with melatonin or placebo for 4 weeks and after washout period, patients who started with melatonin were switched to placebo. Melatonin was administered 30 minute before bedtime in dose of 0.3 mg /kg from 3 mg tablets.Results:In this pilot study, the investigators examined the effect of melatonin on seizures, sleep quality, and behavior in 20 patients that 11 (55 ) child patients were male .The range and mean (SD) of age of patients were 2 to 13 year and 7.28 -epileptic drugs. Further trials for these patients surgery, vagal nerve stimulation, and the ketogenic diet, can reduce seizure frequency. Effects of melatonin treatment in seizures have been evaluated in several studies with different methods, many of which have confirmed this effect.Methods:In a pilot crossover study children with drug-Introduction:About 15 of children with seizures are refractory to standard anti‬▒‭3.46 year, respectively The mean number of diurnal seizures in the study group during placebo treatment was 11.05 and during melatonin treatment 6.25 ,That was statistically significant (P = .021, Wilcoxon Test) but the reduction of mean duration of diurnal seizures in the study groups was not statistically significant (P = .386, Wilcoxon Test) and There was not any correlation between decreasing in seizures number and duration after melatonin administration and before or after melatonin plasma levels.Conclusions:melatonin has probable benefit effect in some patients with seizure with not really known mechanisms, that the physicians can fortunate in trouble patients and even with rescue or seizure freedom treatment intend.‬
 
 
 
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