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رکورد قبلیرکورد بعدی
نوع مدرک : TF
زبان مدرک : فارسی
شماره رکورد : 66973
شماره مدرک : ‭پ۵۳۴۶۹‬
شماره راهنما : ‭ت۲۶۵۶‬
سر شناسه : سحابی، رضا
عنوان اصلي : بررسی میزان بیان‭COX_2‬ در نوروبلاستوم و ارتباط آن با فاکتورهای کلینیکوپاتولوژیک
نام عام مواد : [پایان‌نامه]
نام نخستين پديدآور : /رضا سحابی
نام ساير پديدآوران : ؛استاد راهنما: امیر حسین جعفریان، ننا زابلی نژاد
نام ساير پديدآوران : ؛استاد مشاور: نعما محمدیان روشن، حمید فرهنگی، سعید اخلاقی
عنوان ديگر : عنوان به انگلیسی‭Evaluation of COX_2 expression in neuroblastoma and it's relationship with clinicopathologic factors :‬
وضعيت نشر : دانشگاه علوم پزشکی مشهد، ‭۱۳۹۱‬، دانشکده پزشکی
صفحه شمار : ‮‭[۹۰]‬ ص.‬: مصور
يادداشت : چکیده فارسی، چکیده انگلیسی
يادداشت : چاپی
خلاصه يا چکيده : ‭2 levels decreased with increasing maturity and differentiation. Inversely high expression has related with aggressive behavior of neuroblastoma.-2 has a central role in Growth, differentiation and the amount of cell apoptosis ,so that the expression of cox-2 staining and the type of tumor, histologic grade, karyorrhectic index and microvessel density. So that the intensity and the amount of staining was higher in the Neuroblastoma group than ganglioneuroblastoma , weakly in 3 ganglioneuroma as the control group. In addition, age more than one year old independently increased the rate of relapse and no response to treatment.Conclusion: Cox-2 and VEGF by immunohistochemistry in 49 paraffin blocks confirmed the diagnosis of neuroblastoma and ganglioneuroblastoma, Percentage and staining intensity were compared with factors such as age, sex, tumor histologic grade, clinical stage, tumor response to treatment , recurrence rates and tumor microvessel density.Results: In the 49 cases (40 cases of neuroblastoma and 9 ganglioneuroblastoma), there was statistical significance relationship (p value 0.05) between the total score for cox-induced angiogenesis and metastases. However few researches has been done on the relationship between cox2 expression with histological grade and prognosis in neuroblastoma.Method: we analyzed the expression of COX-2 in tumoral cells is responsible for resistance to apoptosis, stimulate cell proliferation, invasion , tumor-Background: Neuroblastoma is the most common extracranial solid malignant tumor in children. Despite multiple drug therapies, the patients prognosis is very poor. As yet the known prognostic factors in neuroblastoma like age and tumor histologic grade is cited. Increased expression of cox‬
 
 
 
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