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رکورد قبلیرکورد بعدی
نوع مدرک : TF
زبان مدرک : فارسی
شماره رکورد : 66904
شماره مدرک : ‭پ۵۳۴۰۹‬
شماره راهنما : ‭ت۲۶۰۸‬
سر شناسه : صالحی، فروغ
عنوان اصلي : بررسی رابطه هیپوتیروئیدی اتوایمیون تحت بالینی و یافته های سرمی واکوکاردیوگرافی آترواسکلورز
نام عام مواد : [پایان‌نامه]
نام نخستين پديدآور : /فروغ صالحی
نام ساير پديدآوران : ؛استاد راهنما: زهره موسوی، هورک پورزند
نام ساير پديدآوران : ؛استاد مشاور: محمد خواجه دلویی، هاله رکنی یزدی
عنوان ديگر : عنوان به انگلیسی‭Correlation of autoimmune subclinical hypothyroidism with serum and echocardiographic findings of atherosclerosis :‬
وضعيت نشر : دانشگاه علوم پزشکی مشهد، ‭۱۳۹۱‬، دانشکده پزشکی
صفحه شمار : ‮‭[۹۴]‬ ص.‬: مصور (رنگی‭(‬
يادداشت : چکیده فارسی، چکیده انگلیسی
يادداشت : چاپی
خلاصه يا چکيده : ‭0.8 ; p= 0.006 ) were significantly different in Sch patients versus matched controls. There was no significant difference in the serum level of hs CRP (p=0.9), Ferritin (p=0.8), Homocysteine (p=0.3) between patients with Sch and controls.TSH negatively correlated with Sm (r= -0.3, p=0.005) and Em (r = - 0.2, p=0.03) and positively correlated with longitudinal systolic strain rate. (SRs: r = 0.4, p <0.001. SRl: r =0.4, p =0.001).Conclusion: This study revealed that Sch is associated with and increased CHD risk. We found no association between subclinical hypothyroidism and inflammatory markers ( homocysteine , ferritin , hsCRP) .Our study suggest that the atherogenicity of Sch is not mediated by inflammatory markers . Associated hypertriglyceridemia may explain the observed increased risk of CHD in patients with Sch . Subclinical Lv dysfunction was observed in Sch group .Echocardiographic parameters might be useful to identify patients who might benefit from replacement therapy.‬ ▒‭0.6 vs 7.43‬ ▒‭0.29; p= 0.001)) and Sm of septal mitral annulus( 6.90‬ ▒‭0.27 vs -1.68‬▒‭0.16; p= 0.002, SRl:-1.43‬ ▒‭0.4 vs -1.26‬ ▒‭2.99; p= 0.002) and Echocardiographic parameters (longitudinal systolic strain rate (SRs:-1.006‬ ▒‭2.66 vs 13.48‬ ▒‭0.67; p= 0.04) , Free T4 (11.12‬ ▒‭0.92 vs 3.29‬ ▒‭41.57; p= 0.03), total cholesterol to HDLc ratio (3.73‬ ▒‭63.51 vs 86.86‬ ▒‭Objectives: Subclinical hypothyroidism (Sch) is the most frequent thyroid disease. As many as 10-15 of older women have Sch and thyroid autoimmunity. Mild thyroid gland failure may be associated with increased morbidity, particularly for cardiovascular disease. The aim of this study was to assess whether Sch could be associated with increased risk of coronary heart disease. We investigated risk factors for atherosclerosis ( lipid profile , hsCRP , homocysteine , ferritin ) and echocardiographic indices and their relationships with thyroid hormone in Sch patients and controls.METHODS: We Examined 30 Patient with Sch and 30 healthy controls. Sch was defined as an elevated thyrotropin (4.5<TSH<10 mu/l) and normal free T4 (FT4). Serum TSH measurement was repeated at least after one months to confirm the diagnosis. None of the patient has been previously treated with thyroxin. in all participants , we determined body mass index ( BMI ), blood pressure, Fasting blood glucose , TSH , FT4 , TPO ab, Lipid profile status , hsCRP, Homocysteine , ferritin . Echocardiography was done in all subjects and tissue Doppler imaging and speckle tracking were used to evaluate regional and global left ventricular systolic function. Results: Level of triglyceride (117.43‬
 
 
 
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