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رکورد قبلیرکورد بعدی
نوع مدرک : TF
زبان مدرک : فارسی
شماره رکورد : 66841
شماره مدرک : ‭پ۵۳۳۶۵‬
شماره راهنما : ‭ت۲۷۴۹‬
سر شناسه : شیخی، وحید
عنوان اصلي : تعیین اثر افزودن متیل پردنیزولون بر کاهش سطح ادراری اینترلوکین‭ ۶ ‬و اینترلوکین‭ ۸ ‬در کودکان با پیلونفریت حاد
نام عام مواد : [پایان‌نامه]
نام نخستين پديدآور : /وحید شیخی
نام ساير پديدآوران : ؛استاد راهنما: محمد اسماعیلی
نام ساير پديدآوران : ؛استاد مشاور: محمد تقی شاکری، سیمین هیرادفر
عنوان ديگر : عنوان به انگلیسی‭The effect of Methyl perdnisolone on urinary level of interleukin-6 and interleukin-8 in children with acute pyelonephritis :‬
وضعيت نشر : دانشگاه علوم پزشکی مشهد، ‭۱۳۹۱‬، دانشکده پزشکی
صفحه شمار : ‮‭[۶۳]‬ ص.‬: مصور
يادداشت : چکیده فارسی، خلاصه انگلیسی
يادداشت : چاپی
خلاصه يا چکيده : ‭20`c used for cytokine measurement. Results: Urinary level of IL6 and IL8 were high in the case and control groups prior to initiation of medication(33.58-Background: Urinary tract infection is common in childhood.urinary tract infection complications such as hypertension, renal scar, chronic renal failure are frequently occurs who may can lead to dialysis and renal transplantation. U T I is the most frequent infection following the upper respiratory tract infection. Cytokines play a major role in renal scar formation following pyelonephritis. Subject of this study is the efficacy of the use of steroid in decrease of urinary level of cytokines. at this study we investigated the role of 5mg/kg intravenous methylprednisolone combined with antibiotics in diminishing urinary interleukin6 and interleukin8 concentration during acute phase of pyelonephritis compared with standard anti biotic therapy. Methods: Urinary IL6 and IL8 concentration were determined by enzyme immunoassay in 25 children whit pyelonephritis who were treated with ceftriaxone plus 5mg/kg intravenous methylprednisolone (case group) and in 25 children with same diagnosis treated with ceftriaxone alone (control group).urine sample obtained at the time of presentation prior to drug administration and at follow up 72 houres after initiation of medication.Urine sample stored at‬▒‭22.46 pg/ml, 176‬▒‭225.11 pg/ml and 27.26‬▒‭24.28 pg/ml, 90.76‬▒‭92.21 pg/ml respectively) in compare with normal population .urinary levels of iterleukin6 and interleukin 8 were decrease at two groups after treatment in comparing with before treatment and this difference was significantly valuable.in addition, combined ceftriaxone and methylprednisolone significantly decrease (p<0/01) urinary level of IL6 (three folds) and IL8 (eleven folds) in case group 72 hours after initiation of medication compared with control group. Measurement of cytokines: IL6 and IL8 were measured by using an enzyme linked immune sorbent assay (ELISA) method. detection kits were interleukin6 and interleukin8 kits that were made in eBioscience co of Austria. Data were expressed as the mean‬▒‭SD. normality of data were assessed with Kolmogrov Smirnov test and we found that distribution of data at each group were not normal, thus data assessed with non para metric Wilcoxon test for compaire differences of pre and post medication urinary interleukin 6 and 8 levels between case and control group. There is no significant difference in mean age(P = 0.819), gender distribution(P = 0.334)of two groups(P>0/1).all of the patients were febrile and E.coli was the commonest microbial germ who reported from urine cultures in two groups. Erythrocyte sedimentation rate from 63/8‬ ▒‭29/3 at case group decrease to 44/5‬▒‭17/1 and this decrease had significant difference(P<0/01). Conclusion: We conclude that intravenous methylprednisolone combined with antibiotics significantly decrease urinary IL6 and IL8 levels in patients with acute pyelonephritis .this suggests that the clinical use of corticosteroids may prevent scar formation following pyelonephritis. Keyword: Cytokine, Interleukin6, Interleukin8, Pyelonephritis, Urinary tract infection‬
 
 
 
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