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نوع مدرک : TF
زبان مدرک : فارسی
شماره رکورد : 66768
شماره مدرک : ‭پ۵۲۳۳۵‬
شماره راهنما : ‭ت۲۶۱۷‬
سر شناسه : قنائی، امید
عنوان اصلي : مقایسه پاسخ دو رژیم درمانی استروئید به تنهایی و ترکیبی استروئید و آزاتیوپرین در بیماران مبتلا به هپاتیت اتوایمن براساس‭staging‬ پاتولوژی
نام عام مواد : [پایان‌نامه]
نام نخستين پديدآور : /امید قنائی
نام ساير پديدآوران : ؛استاد راهنما: موسی الرضا حسینی
نام ساير پديدآوران : ؛استاد مشاور: منور افضل آقائی
عنوان ديگر : عنوان به انگلیسی‭Using pathologic staging for selection of therapeutic regimen in autoimmune hepatitis: acohort study :‬
وضعيت نشر : دانشگاه علوم پزشکی مشهد، ‭۱۳۹۱‬، دانشکده پزشکی
صفحه شمار : ‮‭[۶۷]‬ ص.‬: نمودار
يادداشت : چکیده فارسی، چکیده انگلیسی
يادداشت : چاپی
خلاصه يا چکيده : ‭Background: Since the role of pathological stage of the liver in the success rate of autoimmune hepatitis (AIH) (prednisolone alone or in combination with azathioprine) is unclear, the aim of this study was assessment of the response rate of treatment regimens of AIH according to the fibrosis stages. Method: This observational cohort study was done on 94 AIH patients from 2008 to 2011 in Mashhad, Iran. Patients had received prednisolone alone or in combination with azathioprine treatment regimen and followed every month for six month. The patients divided into three groups based on the before treatment liver biopsy: mild (stage 1, 2) , moderate (stage 3, 4) and severe fibrosis (stage 5, 6). response to the treatment regimen was compared among groups. Findings: The mean age of patients was 31 year and 54 (57 ) patients were female. The results of liver biopsies were as follow: mild fibrosis in 25 (27 ) patients, moderate fibrosis in 30 (32 ) and severe fibrosis in 39 (41 ). Overall 48 patients (51 ) had received prednisolone alone and 46 patients (49 ) had received combination therapy. Overall 61 patients (65 ) had response to treatment regimen. The response rate was much lower in severe fibrosis group in comparison with others (P<0.001). In addition, the response rate of combination therapy was much higher in the severe fibrosis group. Discussion: Our findings showed that the response rate of AIH patients decreases with increasing the liver pathological stage (fibrosis) and pathological stage could help in selecting single or combination regimens. So, prednisolone alone is recommended for mild and moderate fibrosis while combination therapy should reserve for severe fibrosis. Keyword: Autoimmune hepatitis, treatment regimen, Liver fibrosis‬
 
 
 
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